Glucose-6-Phosphate Dehydrogenase Deficiency and Neonatal Hyperbilirubinemia: Insights on Pathophysiology, Diagnosis, and Gene Variants in Disease Heterogeneity
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a prevalent condition worldwide and is caused by loss-of-function mutations in the G6PD gene.Individuals with deficiency are more susceptible to oxidative stress which leads to the classical, acute hemolytic anemia (favism).However, G6PD deficiency in newborn infants presents with an increased